Role of Klotho in Chronic Calcineurin Inhibitor Nephropathy
نویسندگان
چکیده
منابع مشابه
Campath, calcineurin inhibitor reduction and chronic allograft nephropathy (3C) study: background, rationale, and study protocol
BACKGROUND Kidney transplantation is the best treatment for patients with end-stage renal failure, but uncertainty remains about the best immunosuppression strategy. Long-term graft survival has not improved substantially, and one possible explanation is calcineurin inhibitor (CNI) nephrotoxicity. CNI exposure could be minimized by using more potent induction therapy or alternative maintenance ...
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The first successful transplantation of a human kidney was performed more than 50 years ago by Murray and colleagues in 1954 between identical twins. The success of this transplantation was due to the fact that no significant rejection occurs between genetically identical twins and therefore immunosuppression was not necessary in this particular case (Merrill et al., 1956). However, solid-organ...
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15 صفحه اولChronic calcineurin inhibitor nephrotoxicity: reflections on an evolving paradigm.
Use of the calcineurin inhibitors (CNI) cyclosporine and tacrolimus has revolutionized solid organ transplantation. For more than 30 yr, the transplant community has dealt with nephrotoxicity attributed to these agents. Acute renal vasoconstriction (as described by many investigators, including John Curtis and colleagues) is the unequivocal consequence of their use; chronic CNI nephropathy, alt...
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ژورنال
عنوان ژورنال: Oxidative Medicine and Cellular Longevity
سال: 2019
ISSN: 1942-0900,1942-0994
DOI: 10.1155/2019/1825018